Dating with a balloon cell nevus hmb45

, because spitz nevi often exhibit a rapid growth phase, the presence of numerous typical mitoses within the superficial dermal component of an otherwise classic spitz nevus does not specifically suggest melanoma. spitz nevi often lack distinctive epidermal changes but often display a fibrotic/desmoplastic stromal reaction and may then be classified as a desmoplastic spitz nevus or desmoplastic nevus (see the images below).: clear cell sarcoma, genetic studies, malignant melanomaintroductionclear cell sarcoma (ccs) is a rare neoplasm with a difficult clinical and histological differential diagnosis. nevus may still be regarded as a clinically and histologically distinct variant of melanocytic nevus composed of spindled and/or epithelioid melanocytes (in the configuration of a benign tumor).: pmc2807157clear cell sarcoma: a case mimicking primary cutaneous malignant melanomam rodríguez-martín, m sáez-rodríguez, b esquivel,1 r sánchez gonzáalez, a noda cabrera, and a martín herrera1from the departments of dermatology, hospital universitario de canarias, university of la laguna, 38320 – la laguna, tenerife, spain1from the department of pathology, hospital universitario de canarias, university of la laguna, 38320 – la laguna, tenerife, spainaddress for correspondence: dr. inspection of a formalin-fixed specimen containing a spitz nevus parallels its clinical and dermoscopic appearance and does not yield diagnostically conclusive information. a rare variant of sarcoma mimicking clear cell melanoma was diagnosed based on the genetic studies. neoplastic cells did not express ck, ema, synaptophysin, chromogranin, sma, desmin, cd117 and cd68. histologic variants include polypoid, plexiform, angiomatoid, hyperpigmented, combined, halo spitz nevus, and recurrent spitz nevus. cytogenetic comparison between clear cell sarcoma and a case of acral clear cell melanoma.

Dating with a balloon cell nevus summary

malignant melanoma of the choroid with balloon cells a clinicopathologic study of three cases. metastatic clear cell tumors of renal or adrenal origin as differential diagnoses may entirely derail the focus of diagnostic work-up. mechanisms of cell-cycle arrest in spitz nevi with constitutive activation of the map-kinase pathway. balloon cells in bcm do not contain mucin; glycogen or lipid is variable; while a few demonstrate staining for masson's fontana. clear cell sarcoma of soft tissue: a clinicopathologic, immunohistochemical, and molecular analysis of 33 cases. tumor was dominantly composed of a large central 'white' spheroid island populated by sheets of large-sized cells with abundant clear to finely vacuolated cytoplasm [figure 1]..> abstract balloon cell melanoma (bcm) is a rare histologic variant of cutaneous malignant melanoma with exceptional reports of occurrences at non-cutaneous sites. "atypical" spitz's nevus, "malignant" spitz's nevus, and "metastasizing" spitz's nevus: a critique in historical perspective of three concepts flawed fatally. intraepithelial growth may occur, but if such growth is present, it is ideally most prominent in the central portion of the tumor and often manifests as transepidermal elimination or expulsion of nests of melanocytes rather than single cells; this manifestation must be distinguished from "consumption of the epidermis," a phrase used to describe the thinned epithelium overlying junctional nests and associated epidermal atrophy that favors melanoma over spitz nevus. dual-color, break apart fluorescence in situ hybridization for ews gene rearrangement distinguishes clear cell sarcoma of soft tissue from malignant melanoma.

Dating with a balloon cell nevus picture

cells were disposed in nests separated by fibrous connective tissue. is characterized by presence of eponymous balloon cells; their close semblance to foam cells projects an alarmingly deceptive facade that belies their malignant nature. nevus has been characterized as relatively uncommon: it is estimated to account for only about 1% of surgically removed nevi. however, there is evidence that cell proliferation in spitz nevi, as in other types of nevi and in melanoma, is primarily mediated by activating mutations affecting genes in the ras-raf-mek-erk-map kinase pathway. however, vessels with tumor cells emanating from the vascular muscle coat are a morphological clue in pecoma whereas structurally normal vessels are present as bystanders in bcm. nevus has been characterized as relatively uncommon: it is estimated to account for only about 1% of surgically removed nevi., because spitz nevi often exhibit a rapid growth phase, the presence of numerous typical mitoses within the superficial dermal component of an otherwise classic spitz nevus does not specifically suggest melanoma. spitz nevi often lack distinctive epidermal changes but often display a fibrotic/desmoplastic stromal reaction and may then be classified as a desmoplastic spitz nevus or desmoplastic nevus (see the images below). nevi with epithelioid melanocytes and immunohistochemical loss of bap1 expression (so-called bapoma or wiesner nevus) define a distinct form of tumor that in some cases may be associated with a heritable melanoma syndrome characterized by increased risk for ocular melanoma. a zonal arrangement separated the varied tumor cells where the most superficial, polypoid area showed large, clear polygonal balloon cells; the mid-dermal zone demonstrated a transition between balloon cells, epithelioid cells, and spindle cells; and the deep dermal zone had storiform arrangement of spindle cells, with the fascicles separated by coarse collagen bundles.

Dating with a balloon cell nevus

pathology findings biopsy revealed ulcerated mucosa with sheets of large sized clear cells underneath., spitz nevus has also been described under the headings of juvenile melanoma, benign juvenile melanoma, and prepubertal melanoma. clear cell variant of malignant melanoma of the uterine cervix: a case report and review of the literature. histopathologic criteria that support the classification of ccs as a separate entity include the presence of spindle and clear cells, absence of nuclear atypia, and small and inconspicuous nucleoli. in this case, we used the lsi chop (12q13) dual color, break apart rearrangement probe (abbott laboratories), which showed the nuclei of normal cells . pigmented spindle cell nevus (reed nevus) is regarded by most authorities as a clinically and histologically distinct variant of spitz nevus. intraepithelial growth may occur, but if such growth is present, it is ideally most prominent in the central portion of the tumor and often manifests as transepidermal elimination or expulsion of nests of melanocytes rather than single cells; this manifestation must be distinguished from "consumption of the epidermis," a phrase used to describe the thinned epithelium overlying junctional nests and associated epidermal atrophy that favors melanoma over spitz nevus. herein, we describe the clinicopathologic findings of balloon cell df arising on the heel of a 43-year-old man. variable sized vessels traversed the sheets of pale cells; their muscular coats notably lacked radiating epithelioid or spindle cells. histologically, the tumor was characterized by sheets of pale cells that bore striking resemblance to foamy macrophages.

Balloon Cell Malignant Melanoma in a Young Female: A Case

the nuclei of these cells are more often vesicular than hyperchromatic (see the image below). spindle cell and epithelioid cell nevi with atypia and metastasis (malignant spitz nevus). recognition of atypical spitz tumors (ast) reflects the fact that some melanocytic proliferations exhibit microscopic features (and biologic behavior) intermediate between classic spitz nevus and melanoma. this lesion is a variant of melanocytic nevus, there is no staging classification for a correctly diagnosed spitz nevus. however, eosinophilic nucleoli represent a common feature of spitz nevus and melanoma.[14] spitz nevus affects males and females, and the majority arise before the age 20 years. differentiation from the clear or spindle-cell neoplasms, metastatic mm, and unusual mm subtypes is an essential component in patient management. nevus most commonly arises on the skin of the head and neck or the extremities (more commonly on the lower extremities than on the upper). although a minority or markedly enlarged or pleomorphic cells may be seen, nuclear pleomorphism, chromasia, and nucleolation are fairly uniform through the tumor, with evidence of maturation (detailed below). thus, spitzoid proliferations, especially pure spindle cell or pure epithelioid cell melanocytic proliferations on skin with severe solar elastosis usually represent melanoma.

CLEAR CELL SARCOMA: A CASE MIMICKING PRIMARY

spindle cell nevus (reed nevus) is either a junctional or a superficial compound proliferation. is a recently described variant of sarcoma characterized by prominent clear cell features similar to clear cell melanoma. other uncommon mimics include tumors that infrequently display a clear cell phenotype such as myoepithelial carcinoma, neuroendocrine tumor (net), gastrointestinal stromal tumor (gist), epithelioid leiomyomatous tumor, sebaceous carcinoma and liposarcoma. staining for mitoses using phh3 labels fewer cells than by ki-67 but labels approximately twice the number of cells compared to manual counting of mitoses. when present in melanomas, kamino bodies are usually small and few in number and are often pas negative; such characteristics suggest that these structures actually represent apoptotic cells. spindle cell nevus (reed nevus) on the thigh of a woman. ultrastructurally, the clear tumor cells were filled with multiple, empty, nonmembrane bound vacuoles of varying size. a variant of melanocytic nevus, spitz nevus fulfills all major histologic criteria for the diagnosis of melanocytic nevus, with one or more additional features that distinguish it as spitz nevus. paraganglioma-like dermal melanocytic tumor: a unique entity distinct from cellular blue nevus, clear cell sarcoma and cutaneous melanoma. desmoplastic (sclerotic) nevus: an underrecognized entity that resembles dermatofibroma and desmoplastic melanoma.

Pathology of Spitz Nevi: Overview, Pathophysiology and Etiology

thus, spitzoid proliferations, especially pure spindle cell or pure epithelioid cell melanocytic proliferations on skin with severe solar elastosis usually represent melanoma. presence of rare atypical mitoses confirmed the malignant nature of the cells. in dermis, cells were disposed in nests separated by fibrous connective tissue, showing an alveolar pattern [figure 2c]. clear cell sarcoma of tendons and aponeuroses a study of patients. mechanisms of cell-cycle arrest in spitz nevi with constitutive activation of the map-kinase pathway. the cells possessed central to eccentric, mildly hyperchromatic nuclei and inconspicuous nucleoli. definition, spitz nevi are composed of spindled and/or epithelioid melanocytes; the proportion of spindled versus epithelioid cells varies from case to case. df with balloon cell change, likely secondary to persistent irritation, should be added to the differential diagnosis of cutaneous primary and metastatic neoplasms showing balloon cell degeneration such as balloon cell melanocytic nevi and renal cell carcinoma, respectively. cell sarcoma (ccs) is a recently described variant of sarcoma characterized by prominent clear cells showing features similar to clear cell melanoma. tumoral cells were arranged in sheets or small nests [figure 2a].

Melanocytic Tumors of the Skin: A Dermatopathological Review

spindle cell nevus (reed nevus) on the thigh of a woman. although clear cell df has been described in the literature, balloon cell degeneration causing a clear cell df phenotype has been not been reported to date. clear cell sarcoma of soft tissue: a clinicopathologic, immunohistochemical, and molecular analysis of 33 cases. clear cell soft tissue sarcoma: clinical, histopathological and prognostic study of 36 cases. neoplastic cells were immunoreactive for s100, melan-a, and focally for hmb-45 while were negative for myogenic, gastrointestinal stromal tumor, epithelial and neuroendocrine markers. desmoplastic (sclerotic) nevus: an underrecognized entity that resembles dermatofibroma and desmoplastic melanoma. in a small biopsy that is entirely composed of balloon cells, the latter could be easily mistaken for foamy macrophages and disregarded leading to a repeat biopsy. synonyms include spitz’s nevus, spitz tumor, and spindle and epithelioid cell nevus. on the other hand, erroneous interpretation of clear cells in rectal biopsy as signet ring cells swollen with mucin can be a trapdoor, more often when epithelioid cells are also intermixed.[14] spitz nevus affects males and females, and the majority arise before the age 20 years.

Arare conjunctival spitz nevus: a case report and literature review

spindle cell nevus (reed nevus) is a uniformly heavily pigmented (dark brown-black), well-defined, round macule or minimally elevated papule, usually less than 6 mm in diameter (see the image below)., spitz nevus has also been described under the headings of juvenile melanoma, benign juvenile melanoma, and prepubertal melanoma. spindle cell nevus (reed nevus) on the thigh of a woman. synonyms include spitz’s nevus, spitz tumor, and spindle and epithelioid cell nevus. consumption of the epidermis: a diagnostic criterion for the differential diagnosis of melanoma and spitz nevus. nevus may still be regarded as a clinically and histologically distinct variant of melanocytic nevus composed of spindled and/or epithelioid melanocytes (in the configuration of a benign tumor). clear cell sarcoma of tendons and aponeuroses: a historical perspective and tribute to the man behind the entity. however, eosinophilic nucleoli represent a common feature of spitz nevus and melanoma. these epithelioid cells possessed moderate amounts of cytoplasm and prominent nucleoli. most important differential diagnosis is mm, including metastatic mm with unknown primary site or rare variants as clear cell melanoma or balloon cell melanoma.

Balloon cell nevus - Wikipedia

[8–10]follicular dendritic and interdigitating cell tumors, mpnsts, paraganglioma-like dermal melanocytic tumor, hidradenocarcinoma, perivascular epithelioid cell-omas (pec-omas), clear cell basal cell carcinoma, clear cell syringoma, balloon cell nevus or melanoma, xanthoma, hibernoma, sebaceous neoplasm, atypical fibroxanthoma, or hypernephroma should also be considered. this lesion is a variant of melanocytic nevus, there is no staging classification for a correctly diagnosed spitz nevus. however, there is evidence that cell proliferation in spitz nevi, as in other types of nevi and in melanoma, is primarily mediated by activating mutations affecting genes in the ras-raf-mek-erk-map kinase pathway. the least common denominators for the diagnosis of melanocytic nevus include the following:Symmetrical profile at scanning magnification (including the lymphocytic host response, if present). "atypical" spitz's nevus, "malignant" spitz's nevus, and "metastasizing" spitz's nevus: a critique in historical perspective of three concepts flawed fatally. balloon cell melanoma of the anal canal: a wolf in sheep's clothing?[19] historically, the original series of ast was designated "malignant spitz nevus,". when present in melanomas, kamino bodies are usually small and few in number and are often pas negative; such characteristics suggest that these structures actually represent apoptotic cells. on ihc, clear and non-clear tumor cells were uniformly positive for melan-a and s100. focal positivity for hmb-45 was identified in the peripheral non-clear tumor cells [figure 2].

Melanoma Histopathological Variants

epidermal hyperplasia with vertically oriented spindle cells within vertically oriented junctional nests ("banana clusters"). spindle cell nevus (reed nevus) is a uniformly heavily pigmented (dark brown-black), well-defined, round macule or minimally elevated papule, usually less than 6 mm in diameter (see the image below). as these synonyms imply, the differential diagnosis of spitz nevus and spitzoid melanoma can be among the most challenging in dermatopathology. 2(a) in a low power picture, oval to polygonal in shape cells with a clear cytoplasm and irregular nuclear contours and complex nucleoli can be observed. molecular diagnostic studies to assist in the distinction between spitz nevus and spitzoid melanoma include fluorescence in situ hybridization (fish) and array comparative genomic hybridization (acgh).[19] historically, the original series of ast was designated "malignant spitz nevus,". clear cell sarcoma of tendons and aponeuroses (malignant melanoma of soft parts) and cutaneous melanoma: exploring the histogenic relationship between these two clinicopathological entities. degree of pagetoid growth of single melanocytes in reed nevus, particularly in children, may be greater than that seen in some examples of melanoma in situ (see the image below). 1: balloon cell melanoma, h and e; (a) scanner revealed a pale 'white' tumor composed of sheets of balloon cells underneath rectal mucosa (original magnification, ×20); (b) balloon cells reminiscent of foam cells (original magnification, ×100); (c) epithelioid non-balloon melanoma cells at the periphery (original magnification, ×100); (d) high power view of balloon cells exhibiting bland cytology and empty-looking cytoplasm (original magnification, ×400)click here to viewfigure 2: immunoreactivity of balloon cell melanoma; (a) balloon cells expressed melan a (original magnification, ×20); (b) strong cytoplasmic and nuclear expression for s100 (original magnification ×20); (c) hmb 45 expression was restricted to the non-balloon tumor cells (original magnification, ×20)click here to view  > discussion  bcm is an extremely rare form of malignant melanoma characterized by proliferation of balloon cells.[5–7,11]it is important to be aware with the wide range of clinical and pathological differential diagnosis of clear and spindle-cell neoplasms.

Dating with a balloon cell nevus hmb45

Immunohistochemistry: Current Applications in Skin Cancer | Sigma

recognition of atypical spitz tumors (ast) reflects the fact that some melanocytic proliferations exhibit microscopic features (and biologic behavior) intermediate between classic spitz nevus and melanoma. at the periphery, an attenuated brim of non-clear epithelioid neoplastic cells arranged in nests was seen intermixed with the clear cells [figure 1]. conditions to consider include the following:Melanoma arising in association with melanocytic nevus. on one hand, bcm cells can resemble innocuous foamy macrophages, while on the other bear semblance to innumerable clear cell tumors of gastrointestinal tract. junctional activity could be observed in the tumor, with nests of proliferating melanocytic cells showing cytologic atypia in the basal layer. in pubmed    search pubmed forbal mmramadwar mdeodhar k    search in google scholar for bal mm ramadwar m deodhar k  related articlesanal canalballoon cell melanomadifferential diagnosisimmunohistochemistry. a variant of melanocytic nevus, spitz nevus is a benign neoplasm. nevi with epithelioid melanocytes and immunohistochemical loss of bap1 expression (so-called bapoma or wiesner nevus) define a distinct form of tumor that in some cases may be associated with a heritable melanoma syndrome characterized by increased risk for ocular melanoma. conditions to consider include the following:Melanoma arising in association with melanocytic nevus. of cell proliferation, as measured by cell proliferation markers such as ki-67; a proliferative index greater than 5% supports melanoma; however, a lower proliferative index does not exclude melanoma, and ki-67 labeling greater than 10% has been documented in spitz nevus.

Pathology Outlines - Balloon cell nevus

[1] according to some authors, clear cell sarcoma of tendons and aponeuroses should be the proper name for this rare tumor, to prevent confusion with ccs of the kidney and other clear and spindle-cell neoplasms. spindle cell nevus (reed nevus) is either a junctional or a superficial compound proliferation. although a minority or markedly enlarged or pleomorphic cells may be seen, nuclear pleomorphism, chromasia, and nucleolation are fairly uniform through the tumor, with evidence of maturation (detailed below). epidermal hyperplasia with vertically oriented spindle cells within vertically oriented junctional nests ("banana clusters"). staining for mitoses using phh3 labels fewer cells than by ki-67 but labels approximately twice the number of cells compared to manual counting of mitoses. of cell proliferation, as measured by cell proliferation markers such as ki-67; a proliferative index greater than 5% supports melanoma; however, a lower proliferative index does not exclude melanoma, and ki-67 labeling greater than 10% has been documented in spitz nevus. as these synonyms imply, the differential diagnosis of spitz nevus and spitzoid melanoma can be among the most challenging in dermatopathology. inspection of a formalin-fixed specimen containing a spitz nevus parallels its clinical and dermoscopic appearance and does not yield diagnostically conclusive information. absence of mutations of the braf gene in malignant melanoma of soft parts (clear cell sarcoma of tendons and aponeuroses) cancer genet cytogenet. histologic variants include polypoid, plexiform, angiomatoid, hyperpigmented, combined, halo spitz nevus, and recurrent spitz nevus.

Clinicopathological analysis of one case of the balloon cell nevus

epidermal hyperplasia with vertically oriented spindle cells within vertically oriented junctional nests ("banana clusters"). pigmented spindle cell nevus (reed nevus) is regarded by most authorities as a clinically and histologically distinct variant of spitz nevus. degree of pagetoid growth of single melanocytes in reed nevus, particularly in children, may be greater than that seen in some examples of melanoma in situ (see the image below). the nature of clear cells was difficult to ascertain and were assumed to be macrophages accompanying the scant non-clear epithelioid neoplastic cells. predominantly, the tumor was composed of oval to polygonal cells with clear cytoplasms and enlarged, irregular, hyperchromatic nuclei with nucleoli. mismatch repair proteína and microsatellite instability: a comparison of clear cell sarcoma of soft parts and metastático melanoma. perivascular epithelioid cell tumor (pecoma) and clear cell sarcoma (ccs) are other close impersonators of bcm on account of clear cell morphology and melanocytic differentiation. spindle cell nevus (reed nevus) on the thigh of a woman. the least common denominators for the diagnosis of melanocytic nevus include the following:Symmetrical profile at scanning magnification (including the lymphocytic host response, if present).> introduction  balloon cell melanoma (bcm) is a very rare, albeit, well established histologic variant of malignant melanoma.

An Unusual Melanocytic Nevus of Conjunctiva : Balloon Cell Nevus.

consumption of the epidermis: a diagnostic criterion for the differential diagnosis of melanoma and spitz nevus. a variant of melanocytic nevus, spitz nevus fulfills all major histologic criteria for the diagnosis of melanocytic nevus, with one or more additional features that distinguish it as spitz nevus. nevus typically presents as a solitary, soft, well-demarcated, nonulcerated, dome-shaped papule that is usually less than 6-10 mm in diameter (rarely up to 3 cm) and contains a fairly even degree of pigmentation anywhere within the pink-red-tan–light brown–dark brown color spectrum (see the image below). primary balloon cell malignant melanoma of the right temporo-parietal region arising from meningeal naevus. at the lateral margins, atypical melanocytes nested in dermoepidermal junction [figure 2b], showing features of a remnant nevus in the specimen. excisional biopsy revealed a circumscribed fibrous tumor populated by mostly clear and spindle cells. clear cell sarcoma (malignant melanoma) of soft parts: a clinicopathological study of 30 cases. cell melanoma of the anal canal: a wolf in sheep's clothing? nevus typically presents as a solitary, soft, well-demarcated, nonulcerated, dome-shaped papule that is usually less than 6-10 mm in diameter (rarely up to 3 cm) and contains a fairly even degree of pigmentation anywhere within the pink-red-tan–light brown–dark brown color spectrum (see the image below). the nuclei of these cells are more often vesicular than hyperchromatic (see the image below).

На главную страницу Sitemap